ea0016oc1.5 | Neuroendocrinology and pituitary | ECE2008
Auriemma Renata Simona
, De Martino Maria Cristina
, Galdiero Mariano
, Acampa Wanda
, De Leo Monica
, Lombardi Gaetano
, Cuocolo Alberto
, Colao Annamaria
, Pivonello Rosario
GH and IGF-I excess causes a specific cardiomyopathy, often complicated by diastolic and systolic dysfunction until heart failure. The aim of this study is to evaluate the effects of long-term treatment with pegvisomant on cardiac performance in acromegalic patients. Twelve patients (4 men and 8 women, age 2958 years) entered the study. A radionuclide angiography at rest and during exercise was performed at baseline and after 18 months of treatment with pegvisomant with ...